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Copper complexes can be sensitive to Light exposure Moisture and humidity Elevated temperatures and temperature cycling Repeated freeze thaw cycles when in solution If these are not controlled, the actual material in the vial can change over time

Aromatase inhibitors may be considered but are not uniformly effective (41)

Ageing is the most common factor

Because research-market material is sold outside any approved supply chain, its identity and purity are unverified: trial data describe a characterized study drug, not the contents of an arbitrary vial, so a batch certificate of analysis is the minimum a research setting should require